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-synuclein, which happens to be a primary component of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, which is an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) worry, suggest that dysfunction from the intracellular proteinase methods, like ubiquitin-proteasome method or lysosomal technique, which gets rid of pointles